diff --git a/apps/emqx_gateway/src/emqx_gateway_app.erl b/apps/emqx_gateway/src/emqx_gateway_app.erl
index 01a1aaddd..f0406bcaa 100644
--- a/apps/emqx_gateway/src/emqx_gateway_app.erl
+++ b/apps/emqx_gateway/src/emqx_gateway_app.erl
@@ -45,7 +45,7 @@ load_default_gateway_applications() ->
         fun(Def) ->
             load_gateway_application(Def)
         end,
-        emqx_gateway_utils:find_gateway_definations()
+        emqx_gateway_utils:find_gateway_definitions()
     ).
 
 load_gateway_application(
diff --git a/apps/emqx_gateway/src/emqx_gateway_schema.erl b/apps/emqx_gateway/src/emqx_gateway_schema.erl
index f0e65627f..8c80fc1fa 100644
--- a/apps/emqx_gateway/src/emqx_gateway_schema.erl
+++ b/apps/emqx_gateway/src/emqx_gateway_schema.erl
@@ -75,7 +75,7 @@ fields(gateway) ->
                     }
                 )}
         end,
-        emqx_gateway_utils:find_gateway_definations()
+        emqx_gateway_utils:find_gateway_definitions()
     );
 fields(clientinfo_override) ->
     [
diff --git a/apps/emqx_gateway/src/emqx_gateway_utils.erl b/apps/emqx_gateway/src/emqx_gateway_utils.erl
index 07185ef42..7a0188387 100644
--- a/apps/emqx_gateway/src/emqx_gateway_utils.erl
+++ b/apps/emqx_gateway/src/emqx_gateway_utils.erl
@@ -47,7 +47,7 @@
     listener_chain/3,
     make_deprecated_paths/1,
     make_compatible_schema/2,
-    find_gateway_definations/0
+    find_gateway_definitions/0
 ]).
 
 -export([stringfy/1]).
@@ -564,8 +564,8 @@ make_compatible_schema2(Path, SchemaFun) ->
         Schema
     ).
 
--spec find_gateway_definations() -> list(gateway_def()).
-find_gateway_definations() ->
+-spec find_gateway_definitions() -> list(gateway_def()).
+find_gateway_definitions() ->
     lists:flatten(
         lists:map(
             fun(App) ->
diff --git a/bin/nodetool b/bin/nodetool
index 9a5d5e069..8170e68e2 100755
--- a/bin/nodetool
+++ b/bin/nodetool
@@ -272,7 +272,7 @@ chkconfig(File) ->
     end.
 
 check_license(Config) ->
-    ok = application:load(emqx_license),
+    ok = ensure_application_load(emqx_license),
     %% This checks formal license validity to ensure
     %% that the node can successfully start with the given license.
 
@@ -362,6 +362,27 @@ add_libs_dir() ->
 add_lib_dir(RootDir, Name, Vsn) ->
     LibDir = filename:join([RootDir, lib, atom_to_list(Name) ++ "-" ++ Vsn, ebin]),
     case code:add_patha(LibDir) of
-        true -> ok;
+        true ->
+            %% load all applications into application controller, before performing
+            %% the configuration check of HOCON
+            %%
+            %% It helps to implement the feature of dynamically searching schema.
+            %% See `emqx_gateway_schema:fields(gateway)`
+            is_emqx_application(Name) andalso ensure_application_load(Name),
+            ok;
         {error, _} -> error(LibDir)
     end.
+
+is_emqx_application(Name) when is_atom(Name) ->
+    is_emqx_application(atom_to_list(Name));
+is_emqx_application("emqx_" ++ _Rest) ->
+    true;
+is_emqx_application(_) ->
+    false.
+
+ensure_application_load(Name) ->
+    case application:load(Name) of
+        ok -> ok;
+        {error, {already_loaded, _}} -> ok;
+        {error, Reason} -> error({failed_to_load_application, Name, Reason})
+    end.
diff --git a/changes/ce/fix-10410.en.md b/changes/ce/fix-10410.en.md
new file mode 100644
index 000000000..aa219c96e
--- /dev/null
+++ b/changes/ce/fix-10410.en.md
@@ -0,0 +1,2 @@
+Fix config check failed when gateways are configured in emqx.conf.
+This issue was first introduced in v5.0.22 via [#10278](https://github.com/emqx/emqx/pull/10278), the boot-time config check was missing.